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1

Insight into the Complexation Mode of Bis(nitrilotriacetic acid) (NTA) Ligands with Ni2+ Involved in the Labeling of Histidine-Tagged Proteins

Marie Brellier, Bernard Barlaam, Charles Mioskowski, Rachid Baati

Journal:

Chemistry - A European Journal

Year:

2009

Language:

english

File:

PDF, 976 KB

english, 2009

2

Prolonged and unprolonged complex febrile seizures differently affect frontal theta brain activity

Thébault-Dagher, Fanny, Deguire, Florence, Knoth, Inga Sophia, Lafontaine, Marc-Philippe, Barlaam, Fanny, Côté, Valérie, Agbogba, Kristian, Lippé, Sarah

Journal:

Epilepsy Research

Year:

2020

Language:

english

File:

PDF, 1.40 MB

english, 2020

3

Comparative evaluation of UNEX-based DNA extraction for molecular detection of Cyclospora cayetanensis, Toxoplasma gondii, and Cryptosporidium parvum as contaminants of berries

Temesgen, Tamirat Tefera, Barlaam, Alessandra, Tysnes, Kristoffer R., Robertson, Lucy J.

Journal:

Food Microbiology

Year:

2020

File:

PDF, 1.13 MB

2020

4

Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors

Barlaam, Bernard, Boiko, Scott, Boyd, Scott, Dry, Hannah, Gingipalli, Lakshmaiah, Ikeda, Timothy, Johnson, Tony, Kawatkar, Sameer, Lorthioir, Olivier, Pike, Andy, Pollard, Hannah, Read, Jon, Su, Qibin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2020

File:

PDF, 2.20 MB

2020

5

ChemInform Abstract: New Hydroxylamines for the Synthesis of Hydroxamic Acids.

B. BARLAAM, A. HAMON, M. MAUDET

Journal:

Year:

1999

File:

PDF, 32 KB

1999

6

ChemInform Abstract: Inhibitors of the Tyrosine Kinase EphB4. Part 3. Identification of Non-benzodioxole-Based Kinase Inhibitors.

Catherine Bardelle, Bernard Barlaam, Nigel Brooks, Tanya Coleman, Darren Cross, Richard Ducray, Isabelle Green, Christine Lambert-van der Brempt, Annie Olivier, Jon Read

Journal:

Year:

2011

File:

PDF, 22 KB

2011

7

A short total synthesis of estrone derivatives: A novel 1,3-rearrangement of an allylic nitro group

Bernard Barlaam, Jean Boivin, Laurent Elkaim, Sarah Elton-Farr, Samir Z. Zard

Journal:

Year:

1995

Language:

english

File:

PDF, 626 KB

english, 1995

8

Neutral 5-substituted 4-indazolylaminoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, David G. Acton, Peter Ballard, Robert H. Bradbury, Darren Cross, Richard Ducray, Hervé Germain, Kevin Hudson, Teresa Klinowska, Françoise Magnien, Donald J. Ogilvie, Annie Olivier, He

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

9

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Bernard Barlaam, Peter Ballard, Robert H. Bradbury, Richard Ducray, Hervé Germain, D. Mark Hickinson, Kevin Hudson, Jason G. Kettle, Teresa Klinowska, Françoise Magnien, Donald J. Ogilvie, Annie Olivi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 134 KB

english, 2008

10

New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors

Bernard Barlaam, Mike Fennell, Hervé Germain, Tim Green, Laurent Hennequin, Rémy Morgentin, Annie Olivier, Patrick Plé, Michel Vautier, Gerard Costello

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 126 KB

english, 2005

11

Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Peter Ballard, Bernard C. Barlaam, Robert H. Bradbury, Allan Dishington, Laurent F.A. Hennequin, D. Mark Hickinson, Ian M. Hollingsworth, Jason G. Kettle, Teresa Klinowska, Donald J. Ogilvie, Stuart E

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 143 KB

english, 2007

12

Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Richard Ducray, Peter Ballard, Bernard C. Barlaam, Mark D. Hickinson, Jason G. Kettle, Donald J. Ogilvie, Catherine B. Trigwell

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 129 KB

english, 2008

13

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

Catherine Bardelle, Bernard Barlaam, Nigel Brooks, Tanya Coleman, Darren Cross, Richard Ducray, Isabelle Green, Christine Lambert-van der Brempt, Annie Olivier, Jon Read

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 478 KB

english, 2010

14

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

Bernard Barlaam, Richard Ducray, Christine Lambert-van der Brempt, Patrick Plé, Catherine Bardelle, Nigel Brooks, Tanya Coleman, Darren Cross, Jason G. Kettle, Jon Read

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 353 KB

english, 2011

15

Solid-phase synthesis of hydroxamic acid based TNF-α convertase inhibitors

Bernard Barlaam, Patrice Koza, Julien Berriot

Journal:

Year:

1999

Language:

english

File:

PDF, 752 KB

english, 1999

16

An expedient total synthesis of (±)-estrone derivatives

Bernard Barlaam, Jean Boivin, Laurent El Kaim, Samir Z. Zard

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 238 KB

english, 1991

17

A new synthesis of substituted dienes by reductive elimination of allylic nitro derivatives

Bernard Barlaam, Jean Boivin, Samir Z. Zard

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 265 KB

english, 1993

18

A practical access to allylic sulphones and lactones from allylic nitro compounds

Bernard Barlaam, Jean Boivin, Samir Z. Zard

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 255 KB

english, 1990

19

New hydroxylamines for the synthesis of hydroxamic acids

Bernard Barlaam, Annie Hamon, Mickaël Maudet

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 258 KB

english, 1998

20

Naples Zoological Station

Journal:

Year:

1975

File:

PDF, 129 KB

1975

21

Preparation of 6-aminoquinazolin-4(3H)-ones via direct SNAr on the quinazoline ring

Bernard Barlaam, Craig S. Harris, Jonathan Lecoq, Ha Thi Hoang Nguyen

Journal:

Year:

2012

Language:

english

File:

PDF, 1.88 MB

english, 2012

22

ChemInform Abstract: Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-aminoaryl Pyridine Derivatives.

Remy Morgentin, Bernard Barlaam, Kevin Foote, Lorraine Hassall, Janet Hawkins, Clifford D. Jones, Antoine Le Griffon, Aurelien Peru, Patrick Ple

Journal:

Year:

2012

File:

PDF, 54 KB

2012

23

Représentation de l’action et anticipation : apprentissage d’une nouvelle coordination posture-mouvement au cours de l’adolescence

F. Barlaam, C. Fortin, M. Vaugoyeau, C. Schmitz, C. Assaiante

Journal:

Neurophysiologie Clinique/Clinical Neurophysiology

Year:

2011

Language:

french

File:

PDF, 62 KB

french, 2011

24

Development of action representation during adolescence as assessed from anticipatory control in a bimanual load-lifting task

F. Barlaam, C. Fortin, M. Vaugoyeau, C. Schmitz, C. Assaiante

Journal:

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

25

Pyridazinoquinolinetriones as NMDA Glycine-Site Antagonists with Oral Antinociceptive Activity in a Model of Neuropathic Pain

Bare, Thomas M., Brown, Dean G., Horchler, Carey L., Murphy, Megan, Urbanek, Rebecca A., Alford, Vernon, Barlaam, Christine, Dyroff, Martin C., Empfield, James B., Forst, Janet M., Herzog, Keith J., K

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 297 KB

english, 2007

26

New α-Substituted Succinate-Based Hydroxamic Acids as TNFα Convertase Inhibitors

Barlaam, Bernard, Bird, T. Geoffrey, Lambert-van der Brempt, Christine, Campbell, Douglas, Foster, Steve J., Maciewicz, Rose

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 334 KB

english, 1999

27

Le réglage temporel de l’inhibition musculaire comme signature dynamique de l’apprentissage d’un nouveau contrôle postural

Barlaam, F., Vaugoyeau, M., Fortin, C., Assaiante, C., Schmitz, C.

Journal:

Neurophysiologie Clinique/Clinical Neurophysiology

Year:

2012

Language:

french

File:

PDF, 57 KB

french, 2012

28

Corrélats corticaux des ajustements posturaux anticipés lors de la tâche du garçon de café : maturation du réglage temporel pendant l’adolescence

Barlaam, F., Fortin, C., Vaugoyeau, M., Schmitz, C., Assaiante, C.

Journal:

Neurophysiologie Clinique/Clinical Neurophysiology

Year:

2012

Language:

french

File:

PDF, 65 KB

french, 2012

29

Marqueurs comportementaux et cérébraux de l’organisation centrale de la coordination posture-mouvement et de l’anticipation chez l’enfant

Fortin, C., Barlaam, F., Vaugoyeau, M., Schmitz, C., Assaiante, C.

Journal:

Neurophysiologie Clinique/Clinical Neurophysiology

Year:

2012

Language:

french

File:

PDF, 69 KB

french, 2012

30

Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors

Barlaam, Bernard, Anderton, Judith, Ballard, Peter, Bradbury, Robert H., Hennequin, Laurent F. A., Hickinson, D. Mark, Kettle, Jason G., Kirk, George, Klinowska, Teresa, Lambert-van der Brempt, Christ

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.13 MB

english, 2013

31

Rythme mu et précision temporelle de l’inhibition musculaire : une longue maturation au cours de l’adolescence

Barlaam, F., Fortin, C., Vaugoyeau, M., Schmitz, C., Assaiante, C.

Journal:

Neurophysiologie Clinique/Clinical Neurophysiology

Year:

2014

Language:

french

File:

PDF, 62 KB

french, 2014

32

Body schema building during childhood and adolescence: A neurosensory approach

Assaiante, C., Barlaam, F., Cignetti, F., Vaugoyeau, M.

Journal:

Neurophysiologie Clinique/Clinical Neurophysiology

Year:

2014

File:

PDF, 1.08 MB

2014

33

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Giordanetto, Fabrizio, Green, Stephen, Inghardt, Tord, Hennequin, Laurent, Hancox, Urs, Lambert-van der Brempt, Christine, Morg

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 1.28 MB

english, 2014

34

Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents

Giordanetto, Fabrizio, Barlaam, Bernard, Berglund, Susanne, Edman, Karl, Karlsson, Olle, Lindberg, Jan, Nylander, Sven, Inghardt, Tord

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 2.18 MB

english, 2014

35

A Novel ATM Kinase Inhibitor Effectively Radiosensitizes Glioblastoma in Mice

Karlin, J.D., Tokarz, M., Beckta, J., Farhan, A., Pike, K., Barlaam, B., MacFaul, P., Patel, B., Thomason, A., Tudge, E., Wilson, J., Lau, A., Cadogan, E., Durant, S., Valerie, K.

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2014

Language:

english

File:

PDF, 53 KB

english, 2014

36

272 8-(1-Anilino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxamides as PI3Kbeta/delta inhibitors: structure–activity relationships and identification of AZD8186, a clinical candidate for the treatment of PTEN deficient tumours

Barlaam, B., Cosulich, S., Degorce, S., Fitzek, M., Green, S., Hancox, U., Lambert-van der Brempt, C., Lohmann, J.J., Maudet, M., Morgentin, R., Pasquest, M.J., Peru, A., Ple, P., Saleh, T., Vautier,

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 122 KB

english, 2014

37

Two-Directional Approach for the Rapid Synthesis of 2,4-Bis-Aminoaryl Pyridine Derivatives

Morgentin, Rémy, Barlaam, Bernard, Foote, Kevin, Hassall, Lorraine, Hawkins, Janet, Jones, Clifford D., Le Griffon, Antoine, Peru, Aurelien, Plé, Patrick

Journal:

Synthetic Communications

Year:

2012

Language:

english

File:

PDF, 420 KB

english, 2012

38

Discovery of ( R )-8-(1-(3,5-Difluorophenylamino)ethyl)- N , N -dimethyl-2-morpholino-4-oxo-4 H -chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers

Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Pasque

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

39

Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology

Johannes, Jeffrey W., Almeida, Lynsie, Barlaam, Bernard, Boriack-Sjodin, P. Ann, Casella, Robert, Croft, Rosemary A., Dishington, Allan P., Gingipalli, Lakshmaiah, Gu, Chungang, Hawkins, Janet L., Hol

Journal:

ACS Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

40

Inhibition of PI3K Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel

Hancox, U., Cosulich, S., Hanson, L., Trigwell, C., Lenaghan, C., Ellston, R., Dry, H., Crafter, C., Barlaam, B., Fitzek, M., Smith, P. D., Ogilvie, D., D'Cruz, C., Castriotta, L., Wedge, S. R., Ward,

Journal:

Molecular Cancer Therapeutics

Year:

2015

Language:

english

File:

PDF, 1.52 MB

english, 2015

41

Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold

Barlaam, Bernard, Cosulich, Sabina, Fitzek, Martina, Green, Stephen, Harris, Craig S., Hudson, Kevin, Lambert-van der Brempt, Christine, Ouvry, Gilles, Page, Ken, Ruston, Linette, Ward, Lara, Delouvri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.90 MB

english, 2015

42

AZD8931, an Equipotent, Reversible Inhibitor of Signaling by Epidermal Growth Factor Receptor, ERBB2 (HER2), and ERBB3: A Unique Agent for Simultaneous ERBB Receptor Blockade in Cancer

Hickinson, D. M., Klinowska, T., Speake, G., Vincent, J., Trigwell, C., Anderton, J., Beck, S., Marshall, G., Davenport, S., Callis, R., Mills, E., Grosios, K., Smith, P., Barlaam, B., Wilkinson, R. W

Journal:

Clinical Cancer Research

Year:

2010

Language:

english

File:

PDF, 880 KB

english, 2010

43

Synthesis of Novel Hydroxymethyl-Substituted Fused Heterocycles

Holmes, Jane, Almeida, Lynsie, Barlaam, Bernard, Croft, Rosemary, Dishington, Allan, Gingipalli, Laksmaiah, Hassall, Lorraine, Hawkins, Janet, Ioannidis, Stephanos, Johannes, Jeffrey, McGuire, Thomas,

Journal:

Year:

2016

Language:

english

File:

PDF, 245 KB

english, 2016

44

Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morgentin, Rémy, Péru,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.17 MB

english, 2016

45

Applying early discovery safety science to eliminate chemical toxicity and improve the pre-clinical efficacy of focal adhesion kinase inhibitors

Anderton, M., Ashton, S., Barlaam, B., Jones, C., Jones, C.

Journal:

Toxicology Letters

Year:

2015

Language:

english

File:

PDF, 67 KB

english, 2015

46

Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Degorce, Sébastien L., Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan Paul, Ducray, Richard, Glossop, Steven C., Hassall, Lorraine A., Lach, Franck, Lau, Alan, McGuire, Thomas M., Nowak, Thorste

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 1017 KB

english, 2016

47

General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Varnes, Jeffrey G., McGuire, Thomas, Meadows, Rebecca E., Barlaam, Bernard, Clark, Jemma, Cook, Calum R., Davison, Gemma, Dishington, Allan, Savi, Chris De, Donald, Craig, Grebe, Tyler, Hande, Sudhir,

Journal:

Tetrahedron Letters

Year:

2016

Language:

english

File:

PDF, 303 KB

english, 2016

48

Identifying high quality, potent and selective inhibitors of ATM kinase: Discovery of AZD0156

Barlaam, B., Pike, K.

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 56 KB

english, 2016

49

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML

Morgado-Palacin, I., Day, A., Murga, M., Lafarga, V., Anton, M. E., Tubbs, A., Chen, H.-T., Ergen, A. V., Anderson, R., Bhandoola, A., Pike, K. G., Barlaam, B., Cadogan, E., Wang, X., Pierce, A. J., H

Journal:

Science Signaling

Year:

2016

Language:

english

File:

PDF, 3.92 MB

english, 2016

50

Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, Bernard, Cosulich, Sabina, Degorce, Sébastien, Ellston, Rebecca, Fitzek, Martina, Green, Stephen, Hancox, Urs, Lambert-van der Brempt, Christine, Lohmann, Jean-Jacques, Maudet, Mickaël, Morge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 611 KB

english, 2017

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